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电话：010-52995241/57181307
地址：北京市朝阳区西坝河中里35号12信箱，邮编：100028
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摘要：
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流式免疫分型作为血液系统肿瘤的一个重要的辅助检查手段.目前在多发性骨髓瘤(MM)的诊断,预后评估及微小残留病检测方面的价值,已经被越来越多的学者认同,本文就将在MM的免疫表型特点,在临床中的应用进展作一个综述.
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基金项目：
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作者简介：
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参考文献：
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秦燕.丁润生.陆伟.刘红 多参数流式细胞术在多发性骨髓瘤诊断中的价值 [期刊论文] -交通医学2009(2) Kara IO.Sahin B.Paydas S Flow cytometric evaluation of bone marrow plasma cells using CD19,CD45,CD56,CD38,and CD138 and correlation with bone marrow infiltration ratio in multiple myeloma patients 2004(11) Garcia-Sanz R.Orfao A.Gonzalez M Primary plasma cell leukemia:clinical immunophenotypic DNA ploidy and cytogenetic characteristics 1999 Adam C Immunophenotypic Differentiation Between Neoplastic Plasma Cells in Mature B-Cell Lymphoma vs Plasma Cell Myeloma 2007 Harada H.Kawano MM.Huang N Phenotypic difference of normal plasma ceils from mature myeloma cells 1993 Ely SA.Knowles DM Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation 2002 Benjamin Van Camp.Durie B G M.Spier C Plasma cells in multiple myeloma express a natural killer cell-associated antigen:CD56 (NKH-1;Leu-19) 1990 Moreau Patients with CD45 negative multiple myeloma receiving high-dose therapy have a shorter survival than those with CD45 positive multiple myeloma 2004(5) Tai YT.Podar K.Gupta D CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma celia 2002(4) Karim Shamsasenjan.Ken-ichiro Otsuyama.Saeid Abroun IL-6-induced activation of MYC is responsiblefor the down-regulation of CD33 expression in CD33 (+) myeloma ceils 2009 Maisnar V.Touskova M.Tichy M The significance of soluble CD138 in diagnosis of monoclonal gammopathies 2006(1) Matsui W.Huff CA.Wang Q Characterization of clonogenic multiple myeloma cells 2004(6) Sahara N.Takeshita A Prognostic significance of surface markers expressed in multiple myeloma:CD56 and other antigens 2004(1) Rawstron A.Barrans S.Blythe D Distribution of myeloma plasma cells in peripheral blood and bone marrow correlates with CD56 expression 1999(1) P Moreau Patients with CD45 negative multiple myeloma receiving high-dose therapy have a shorter survival than those with CD45 positive multiple.myeloma 2004(5) Fernandes MS.Comes EM.Butcher LD Growth Inhibition of Human Multiple Myeloma Cells by an Oncolytic Adenovirus Carrying the CD40 Ligand Transgene 2009 周振海.李幼姬.李娟.罗绍凯.洪文德.李小银 干扰素γ与抗CD20单克隆抗体对骨髓瘤细胞增殖影响的体外研究 [期刊论文] -中国免疫学杂志2004(2) Kapoor P.Greipp PT.Morice WG Anti-CD20 monoclonal antibody therapy in multiple myeloma 2008(2) Hayashi T.Treon SP.Hideshima T Recombinant humanized anti -CD40 monoclonal antibody triggers antolognus antibody-dependent cell-mediated cytotoxicity against multiple myeloma ceils 2003(4) 吴冠宇 多参数流式细胞术检测多发性骨髓瘤免疫表型及意义 2005(1)
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